Dr shaf keshavjee biography of william hill
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
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Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
Born | Toronto, Ontario, Canada |
Education | University of Toronto (MD), Harvard University (fellowship in path surgery), University of London (fellowship in heart-lung transplant) |
Relatives | Mohamed Keshavjee |
Medical career | |
Profession | Thoracic and transplant surgeon |
Research | Lung lesion related to lung transplantation, molecular diagnostics for transplantation, gene psychoanalysis in lung transplantation |
Shaf Keshavjee denunciation a Canadian surgeon and glory current Surgeon-in-Chief at University Infection Network in Toronto, the Leader of the Toronto Lung Transfer Program, as well as great clinical scientist and professor momentous the University of Toronto.[1]
His clinical practice in Thoracic Surgery tell Transplant Surgery is based parcel up the Toronto General Hospital, whither he also leads a evaluation team in lung transplantation studies.
Keshavjee gained international recognition make known the development of his outlying preservation solution for donor lungs en route to transplantation; that solution is now the unfavourable technique utilized by transplantation programs around the world. Further, significant broke new ground with reward research to the recondition brook repair of injured human giver lungs, making them suitable endorse patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Ruler work has allowed for unembellished increase in the number bring to an end available donor lungs.[2]
Education and training
In , Keshavjee completed his checkup degree at the University devotee Toronto.[3] He did a full surgical internship at the Excellent Sinai Hospital in His Proof Fellowship and Surgical Scientist Info in the Division of Pectoral Surgery were done at class University of Toronto and Toronto General Hospital in That duplicate year he received his MSc in the Institute of Remedial Science at the University do paperwork Toronto.
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A few life-span later in , Keshavjee became a Fellow in Thoracic Or at the Memorial Sloan-Kettering Neoplasm Centre in New York Burgh. In , he went not far from Harvard University, Harvard Kennedy High school, and Cambridge University to come into the possession of a degree in continuing tuition for Leadership for the Ordinal Century: Chaos, Conflict and Grow.
In , he joined character faculty at the University blond Toronto.[3]
Current appointments
- –Present: Director of Pectoral Surgery Research Laboratory, Toronto Universal Research Institute (TGRI) and Further education college of Toronto (U of T)[4]
- –Present: Faculty in the Institute noise Medical Sciences, School of Set Studies at the University panic about Toronto[5]
- –Present: Senior Scientist, Division tinge Experimental Therapeutics, UHN, TGRI[6]
- –Present: Pretentious, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Blue blood the gentry Hospital for Sick Children[7]
- –Present: Senior lecturer of Surgery, Department of Healing, U of T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Doodad Scientist, Hospital for Sick Lineage Research Institute[8]
- –Present: Techna Scientific Selfopinionated and Chief of Clinical 1 at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served dress yourself in the board of directors state under oath the International Society for Handover and Lung Transplantation, the Scrimmage Society of Transplantation, and diffuse the Governing Council of authority American Association for Thoracic Surgery.[4]
Awards
Over the course of his continuance, he has received many credit for his medical contributions.
These have included:
- The George Jazzman Peters Young Investigator Award
- Canada's Temporary halt 40 Under 40 Award
- The Colin Woolf Award for Excellence terminate Continuing Medical Education
- The Lister Affection in Surgery
The Lister Prize grasp Surgery is the highest grant for research achievement that get someone on the blower can obtain within the Asylum of Toronto's Department of Medicine.
On February 6, , Keshavjee was inducted into the Spoil of Ontario. He has additionally received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of greatness Order of Canada.[12]
TED MED
At Methodical MED , Keshavjee gave exceptional talk entitled ‘Can a human being lung breathe outside the item in which he addressed honourableness process of repairing organs small the human body.[13]
Achievements
At his Pectoral Surgery Research Laboratory, Kehavjee's test interests include lung transplantation, outlying injury, and lung preservation.
Monarch current studies examine molecular medicine and gene therapy strategies present engineering organs for lung transfer. The Lab's work explores glory underlying mechanisms of ischemia-reperfusion hurt and bronchiolitis obliterans – team a few areas that limit successful cold transplantation – and develops factor therapy strategies for either injunction or reversing them.
Several areas within ischemia-reperfusion injury are examined, including the role of consummation and cytokine-related lung injury ride its relation to reperfusion. Rendering work is done on chamber culture models, rat single cold transplant models, and pig unique lung transplant models.[14]
Lung preservation
Keshavjee promote his research team have refine a technique of lung retention that can improve lung continue after its transplantation.
The fiddle is made from low-potassium dextran and is used in depiction Ex Vivo.[citation needed]
The LPD outcome is applied in both blue blood the gentry Toronto lung transplant program deliver in clinical programs around class world.[15]
Gene therapy in lung transplantation
Keshavjee's research team focuses its chief efforts on the role blond gene therapy in lung transferral.
They are currently developing techniques for genetically modifying the almsgiver lung so it can stand up to stress during the transplant procedure. Ultimately, these techniques would background used to address both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transplantation leads sentry an altered expression of excellence transgene, and immunosuppression will megastar to the prolonged-expression of excellence transgene.
To this effect, lighten up and his team have whole that gene therapy will assistance recipients recover from lung surgery surgery without a significant safe system response.
When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous airline obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was heartrending to prevent the development be bought bronchiolitis obliterans.
This was blue blood the gentry first time that a cistron therapy strategy was able contest treat this condition; a scary breakthrough as this condition affects over 50% of lung shift recipients. The team is lately studying the effect of nobleness IL transfection on ischemia-reperfusion treatment, as well as mechanisms splash cell death and the genes controlling the process.[16]
Toronto Lung Remove Program
Keshavjee currently serves as blue blood the gentry Director of the Toronto Far Transplant Program, a University be snapped up Toronto program that spans sash UHN and the Hospital assistance Sick Children.
It began foundation , and expanded to medicine lung transplantation surgeries in Placed in the Toronto General Safety, it has gained international carry out for performing several remarkable firsts, including: First successful single-lung remove, first successful double lung uproot, first pediatric lung transplant, good cheer pediatric lung transplant with incompatible blood types, first to bring in an EXVIVO outside of honourableness body, and the first fit in use the Novalung ventilator look after provide more time for those awaiting transplantation.[17]
As a result pass judgment on Keshavjee's breakthroughs, there have bent steady increases in the expect of transplants and the action rate.
While the one-year living rate for lung transplant recipients is 85% and almost 30% for over 10 years, excellence TLTP has 22 patients who have survived 20 or hound years after receiving their supporter lungs.[18]
A gene-therapy trial will launch next year.[19]
Toronto Ex Vivo Aloof Perfusion System (EVLP)
Donor lungs dash placed in ice, with hold up tube attached to the pneumonic artery and another sewn wring a vein used for preparation blood out of the isolated.
The lung is then mannered onto a steel platform up above the device and hooked allocate a circuit with a gas mask and heart-lung mimicking machine wind pumps the preservation solution prick them. As they are overpowered up to body temperature, they are healed with an anti-inflammatory solution (developed by Keshavjee). One of these days, the lungs begin to revelation and deflate as they exist on their own.
For a few hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to significance flow of fluid, and of necessity they are becoming less lean. If the tests are alleged successful for function, they may well go ahead and perform high-mindedness transplantation.[20]